The No. 22 Iowa State Cyclones (5-1) square off against a conference opponent when they visit the Colorado Buffaloes (2-4) on Saturday, October 11, 2025 at Folsom Field in a Big 12 battle.

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Iowa State vs. Colorado Matchup Info

Game date: Saturday, October 11, 2025
Game time: 3:30 p.m. ET
Location: Boulder, Colorado
Venue: Folsom Field
TV channel: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa State vs. Colorado Odds and Prediction

Spread favorite: Cyclones (-2.5)
Moneyline: Cyclones (-137), Buffaloes (+116)
Total: 52 points
Pick ATS: Iowa State (-2.5)
Pick OU: Under (52)
Prediction: Iowa State 29, Colorado 20

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa State vs. Colorado Betting Records and Insights

Iowa State has compiled a 3-2-1 ATS record so far this year.
Colorado has put together a 3-3-0 ATS record so far this year.
The Cyclones have covered the spread twice when favored by 2.5 points or more this season (in four opportunities).
The Buffaloes have been an underdog by 2.5 points or more four times this year, and covered the spread in one of those games.
A total of three out of six Iowa State games this season have hit the over.
So far this year, two Colorado games have hit the over.

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